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MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Regulated mRNA Transport02:22

Regulated mRNA Transport

2.8K
2.8K
tRNA Activation02:26

tRNA Activation

19.0K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
19.0K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

10.6K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
10.6K
Alternative RNA Splicing02:18

Alternative RNA Splicing

21.0K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.0K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

2.8K
2.8K

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相关实验视频

Updated: Jun 9, 2025

Visualizing and Tracking Endogenous mRNAs in Live Drosophila melanogaster Egg Chambers
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Visualizing and Tracking Endogenous mRNAs in Live Drosophila melanogaster Egg Chambers

Published on: June 4, 2019

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结构mRNA是一个基于BERT的模型,用于mRNA表示的双层和有条件掩盖.

Sepideh Nahali1,2, Leila Safari3, Alireza Khanteymoori4

  • 1Information Retrieval and Knowledge Management Research Lab, York University, Toronto, Ontario, Canada. sepidnah@yorku.ca.

Scientific reports
|October 30, 2024
PubMed
概括

基于BERT的新型模型StructmRNA分析了信使RNA (mRNA) 的序列和结构. 它擅长预测RNA降解和二次结构,推进基于RNA的治疗设计.

关键词:
贝尔特 (BERT) 公司双级别的掩盖方式.预测RNA降解的预测代表性的学习学习.结构mRNA的结构的mRNA序列.的mRNA结构结构的mRNA结构.

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Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
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MS2-Affinity Purification Coupled with RNA Sequencing in Gram-Positive Bacteria
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MS2-Affinity Purification Coupled with RNA Sequencing in Gram-Positive Bacteria

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Visualizing and Tracking Endogenous mRNAs in Live Drosophila melanogaster Egg Chambers
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Visualizing and Tracking Endogenous mRNAs in Live Drosophila melanogaster Egg Chambers

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科学领域:

  • 计算生物学 计算生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 了解信使RNA (mRNA) 的进步对于开发新疗法至关重要.
  • 现有的模型通常需要明确的结构数据来进行mRNA分析.
  • 双向编码器表示已经在分析DNA序列方面取得了成功.

研究的目的:

  • 引入基于BERT的模型StructmRNA,用于详细的mRNA序列和结构分析.
  • 将DNA分析模型的功能扩展到mRNA.
  • 为了能够预测mRNA二次结构和治疗设计的生物功能.

主要方法:

  • 开发了一个基于BERT的mRNA分析模型StructmRNA.
  • 实施了一种双层掩盖技术,涵盖了有条件掩盖的序列和结构.
  • 在广泛的数据集上预训练模型,以学习序列结构相关性.

主要成果:

  • 结构mRNA产生有意义的mRNA嵌入,即使没有明确的结构数据.
  • 在RNA降解预测等任务中表现优于现有模型,包括来自斯坦福OpenVaccine项目的模型.
  • 在各种生物体和条件中表现出强大的概括能力.

结论:

  • 结构mRNA代表了mRNA预测分析的重大进步.
  • 该模型可以通过准确预测二级结构和功能,为更好的基于RNA的治疗提供信息.
  • 旨在为基因组学和治疗开发中的mRNA分析设定一个新的标准.