尾切除术和胃肠道癌症之间没有遗传因果关系:在欧洲人口中进行孟德尔随机化研究和元分析
Shuai Wang1, Tao Zhang1, Yuanlin Sun1
1Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Scientific reports
|October 30, 2024
概括
尾切除术,手术切除尾,并没有因果增加欧洲人的胃肠道癌症的风险. 这项遗传研究证实了先前的观察结果,提供了强有力的证据,反对尾切除术和肠道癌症发展之间的联系.
科学领域:
- 遗传学 是一个遗传学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 尾切除术与随后患上胃肠道癌症的风险之间的关系尚未得到充分证实.
- 现有的观测研究对这一关联产生了相互矛盾的结果.
- 需要强有力的遗传证据来澄清尾切除术对胃肠道癌症风险的因果关系.
研究的目的:
- 系统地调查尾切除术对欧洲人口胃肠道癌症风险的潜在因果影响.
- 采用双样本门德尔随机化 (TSMR) 和元分析来评估这种关系.
- 提供支持或反驳尾切除术和胃肠道癌症之间的因果关系的遗传证据.
主要方法:
- 利用两样本的孟德尔随机化 (TSMR),利用来自英国生物银行和FinnGen.com的大规模遗传数据.
- 确定了与尾切除术密切相关的遗传变异作为仪器变量 (IVs).
- 进行元分析,结合发现和复制队伍的结果,评估因果关系.
主要成果:
- 在发现队列中,尾切除术和胃肠道癌症之间没有检测到统计学上显著的因果关系.
- 复制队列分析也没有发现因果关系的证据.
- 综合元分析证实,尾切除术和胃肠道癌症之间没有因果关系.
结论:
- 尾切除似乎对欧洲人口患胃肠道癌症的风险没有因果关系.
- 这些遗传发现与之前的观察性研究的结论一致并加强了这些结论.
- 这项研究提供了强有力的遗传证据,证明尾切除术不会影响胃肠道癌症风险.
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