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Updated: May 12, 2026

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使用Tumoroscope进行瘤异质性的综合空间和基因组分析

Shadi Shafighi1,2,3, Agnieszka Geras1,4,5,6, Barbara Jurzysta1

  • 1Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland.

Nature communications
|October 30, 2024
PubMed
概括

瘤镜是一种新的模型,使用病理图像和基因组数据绘制瘤内的癌症克隆. 这项技术揭示了空间克隆模式和基因表达,以更好地了解瘤组织.

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...