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相关概念视频

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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相关实验视频

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Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
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凝调节肠道干细胞的再生和Th17细胞功能.

Jicong Du1, Lan Fang1, Yuedong Wang1,2

  • 1Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, 800 Xiangyin Road, Shanghai, 200433, P.R. China.

Cell communication and signaling : CCS
|October 30, 2024
PubMed
概括

凝索林在受伤后对肠道干细胞再生至关重要. 它维持了Th17细胞的功能,促进了肠道的愈合,并防止了诸如结肠炎之类的疾病.

关键词:
格尔索林 (Gelsolin) (格尔索林) (英语:Gelsolin) 是一种石材,可以在石头上制造.通过IL-17信号通路传递信号.IR诱导的肠道损伤导致了肠道损伤.肠道干细胞 (ISCs) 是一种干细胞.帮助性T细胞17 (Th17细胞)

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科学领域:

  • 胃肠病学 胃肠病学
  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 肠道干细胞 (ISC) 对于维持肠道平衡和修复损伤至关重要.
  • 凝索林在ISC功能和肠损伤反应中的作用尚不清楚.

研究的目的:

  • 为了研究凝在肠道损伤和再生中的功能.
  • 阐明吉索林影响ISC功能和肠道修复的机制.

主要方法:

  • 电离辐射 (IR) 和DSS诱导的大肠炎模型在Gelsolin淘汰赛 (KO) 小鼠中.
  • 肠道有机体培养和共同培养系统.
  • RNA测序,RT-PCR和流细胞测量分析.
  • 调查了p-STAT3/RORγt信号轴的情况.

主要成果:

  • 凝KO小鼠在IR后表现出增加的辐射敏感性,加重肠道损伤,并减少ISC数量.
  • 凝索林去除损害了ISC功能,并抑制了Th17细胞分化,降低了IL-17信号通路的调节.
  • 重组IL-17A改善了IR引起的损伤,并促进了ISC再生.
  • 凝素缺乏通过p-STAT3/RORγt轴影响了Th17细胞的功能.
  • 在缺乏凝素的有机体中,Th17细胞增强了自我更新.
  • 凝显示出对DSS诱导的大肠炎的保护作用.

结论:

  • 凝对于受伤后的肠道再生至关重要,特别是通过支持ISC功能.
  • 凝索林通过p-STAT3/RORγt通路维持Th17细胞功能来维持ISC再生.
  • 凝在各种形式的肠道损伤中起着保护作用,包括大肠炎.