相关实验视频

Updated: Jun 9, 2025

Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression

Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression

Published on: September 29, 2023

ADAMTS14/rs4747096基因多态性与某些风险因素和膝关节关节炎之间的关联

Ghada A Elshaarawy¹, Iman I Salama², Somaia I Salama²

¹Community Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt. dr.ghada237@gmail.com.

BMC musculoskeletal disorders

|October 30, 2024

概括

ADAMTS14基因rs4747096多态,特别是AA和AG基因型,显著增加了膝关节关节炎 (KOA) 的风险. 老年,致病性肥胖和长时间站立也预测KOA的发展.

科学领域:

遗传学是一个遗传学.
整形外科整形外科整形外科
公共卫生公共卫生

背景情况:

膝关节关节炎 (KOA) 是全球残疾的主要原因之一.
鉴定KOA的遗传和环境风险因素对于公共卫生至关重要.
研究了ADAMTS14基因rs4747096多态性,以确定它在KOA中的作用.

研究的目的:

为了检查ADAMTS14基因rs4747096多态和KOA.之间的关联.
识别导致KOA发展的风险因素.

主要方法:

一项涉及158名KOA患者和120名对照者的病例控制研究.
在ADAMTS14 rs4747096多态的基因定型.
使用WOMAC评分系统和临床检查评估KOA的严重程度.
用于风险因素识别的物流回归分析.

主要成果:

在KOA患者中,ADAMTS14 rs4747096的AA和AG基因型明显更频繁.
在KOA患者中,A等位基因的频率更高 (P<0.05).
高龄 (≥50岁),致病性肥胖 (BMI ≥35) 和长时间站立是KOA的重要危险因素.

结论:

ADAMTS14 rs4747096的AA和AG基因型与KOA的风险增加有关.
亚基因的衰退性遗传模式,晚年,病态肥胖和长时间站立是KOA的预测性风险因素.
建议对更大的队列进行进一步的研究,以阐明这种基因型与KOA病变发生之间的机械联系.

关键词:

亚当斯14基因 rs474709696的基因代基代基代基代基代基还有WOMAC和WOMAC的合作伙伴.基因型基因型基因型科亚科亚是什么意思

更多相关视频

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...