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锡银合金作为生物材料:腐蚀特征和细胞行为

Charley M Goodwin^1,2, Annsley O Mace^1,2, Jeremy L Gilbert^1,2

¹Department of Bioengineering, Clemson University, Clemson, South Carolina, USA.

Journal of biomedical materials research. Part A

|October 30, 2024

概括

锡银 (Sn-Ag) 合金显示出作为可降解的金属生物材料的潜力. 腐蚀测试和细胞研究表明Sn-Ag.

科学领域:

生物材料科学生物材料科学
材料科学材料科学材料科学
生物相容性研究生物相容性研究

背景情况:

锡银 (Sn-Ag) 合金在长期植入物中具有历史性的用途,如牙合金和Essure设备.
关于Sn-Ag的腐蚀行为和细胞相互作用的数据有限,这阻碍了其作为可降解生物材料的应用.

研究的目的:

在模拟生理环境中评估95-5重量%Sn-Ag的腐蚀特性.
评估Sn-Ag合金与小鼠骨质前细胞 (MC3T3-E1) 的生物相容性和细胞反应.

主要方法:

腐蚀测试:开放电路潜力 (OCP),电化学阻抗光谱 (EIS) 和PBS和细胞培养基中的潜在动力极化.
细胞培养研究:在Sn-Ag盘上培养的MC3T3-E1细胞在各种潜力和暴露于SnCl2度.

主要成果:

在PBS中,Sn-Ag表现出被动行为,但在与血清蛋白质的介质中表现出活性极化.
电化学阻抗光谱显示极化电阻在10^5 Ωcm^2范围内,随温度下降.
细胞在OCP和低于分解潜力时很好地附着;阳极极化减少了细胞扩散面积和活力.
锡二) 化物 (SnCl2) 对MC3T3细胞 (LD50 ≈ 0.5 mM) 显示出剂量依赖的细胞毒性作用.

结论:

Sn-Ag合金具有适用于可降解金属生物材料的电化学特性.
细胞反应表明在特定的电化学潜力下潜在的生物相容性.
需要进一步的研究来优化Sn-Ag用于特定的可降解生物材料应用.

关键词:

可生物降解的合金合金细胞相容性细胞相容性两极分化是一种极化.锡银的情况.

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