溶性关酸环酶功能障碍和氧化途径在具有鼻息肉的慢性鼻炎中:术后复发的预测标志物
Sijie Jiang Md1,2,3,4, Caixia Zhang Md1,2,3,4, Zongjing Tong Md5
1Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, China.
American journal of rhinology & allergy
|October 30, 2024
概括
高氧化物 (NO) 途径蛋白,特别是GUCY1A1和GUCY1A2,与慢性鼻炎与鼻复发 (CRSwNP) 有关. 这些蛋白质显示出 CRSwNP 手术后复发的潜在预测因子.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 升高的氧化 (NO) 水平与慢性鼻炎与鼻息肉 (CRSwNP) 中复发风险增加相关.
- 在CRSwNP复发中NO的确切作用仍然不完全理解.
研究的目的:
- 调查NO度与CRSwNP复发风险之间的关系.
- 为了确定与CRSwNP复发相关的特定蛋白质生物标志物.
主要方法:
- 蛋白质芯片阵列分析,以识别CRSwNP患者与健康对照 (HC) 的鼻组织中差异表达的蛋白质.
- 生物信息学分析用于预测蛋白质功能和通路.
- 在独立的队列中进行验证的西部涂抹和免疫组织化学.
- 接收器操作特征 (ROC) 曲线分析,以评估复发的预测能力.
主要成果:
- 在CRSwNP和HC组之间确定了12种不同表达的蛋白质.
- 在CRSwNP.中观察到参与"氧化介导信号传导的积极调节"的蛋白质的上调.
- 关酸环酶1溶解子单元α1 (GUCY1A1) 和GUCY1A2在CRSwNP中显著上调,并与更高的复发风险相关.
- ROC分析证实GUCY1A1和GUCY1A2是术后CRSwNP复发的有效预测因素.
结论:
- CRSwNP患者表现出独特的组织蛋白质概况,涉及NO通路和可溶性酸环酶功能障碍.
- GUCY1A1和GUCY1A2被确定为预测CRSwNP中术后复发的有希望的生物标志物.
关键词:
生物信息学分析分析生物标志物 生物标志物慢性犀牛鼻炎 慢性鼻炎功能性内镜鼻外科手术鼻腔多重体是指鼻腔多重体.氧化氧化的使用方法蛋白质芯片阵列是指蛋白质芯片阵列.接收器的运行特征曲线.复发性 复发性 复发性可溶性甘酸环酸酶可以溶解.更多相关视频
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