在交感神经系统调节中的RGS蛋白:专注于上腺RGS4
Anastasios Lymperopoulos1, Renee A Stoicovy1
1Department of Pharmaceutical Sciences, Laboratory for the Study of Neurohormonal Control of the Circulation, Nova Southeastern University Barry and Judy Silverman College of Pharmacy, Davie/Fort Lauderdale, FL 33328-2018, USA.
Frontiers in bioscience (Landmark edition)
|October 30, 2024
概括
调节G蛋白信号传递4 (RGS4) 调节从交感神经元释放的诺尔上腺素和从上腺细胞分泌的甲醇胺分泌. 准RGS4可能为像高血压这样的交感神经系统疾病提供新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生理学 生理学 生理学
背景情况:
- 交感神经系统 (SNS) 通过来自神经元的北上腺素 (NE) 和来自上腺细胞的上腺素/NE 来调节平衡.
- G蛋白结合受体 (GPCRs) 在很大程度上控制NE的释放和甲醇胺 (CA) 的分泌.
- 调节G蛋白信号 (RGS) 蛋白质,特别是RGS4,作为GTPase激活蛋白 (GAPs) 抑制GPCR信号.
研究的目的:
- 审查RGS蛋白质的作用,重点关注RGS4,调节交感神经元NE释放和上腺色氨酸细胞CA分泌.
- 探索RGS4调制对SNS相关疾病的治疗潜力.
主要方法:
- 对研究RGS蛋白质的文献综述,特别是RGS4.
- 在相关细胞类型中分析RGS4参与终止信号通路 (FFAR3和胆固醇) 的作用.
主要成果:
- RGS4通过抑制自由脂肪酸受体3 (FFAR3) 信号传递来调节心交感神经元的NE释放.
- 通过终止胆固醇信号传递,RGS4控制了从上腺色氨酸细胞分泌的NE和上腺素 (Epi).
- 这些行动凸显了RGS4在调节SNS输出的关键作用.
结论:
- RGS4是神经元中北上腺素释放和上腺素分泌的关键调节者.
- 药理学向RGS4为涉及交感神经系统功能障碍,包括心力衰竭和高血压等疾病提供了有希望的治疗策略.
相关概念视频
Sympathetic Signaling
892
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
892
The Sympathetic Nervous System
94.5K
Overview
94.5K
Sympathetic Division of the ANS
1.7K
The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
1.7K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
1.2K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.2K
Sympathetic Activation
5.1K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.1K
GPCRs Regulate Adenylyl Cylase Activity
5.3K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.3K


