对放射性耐药甲状腺癌的全身治疗方法
Piaohong Chen1, Yu Yao1, Huiwen Tan1
1Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Frontiers in endocrinology
|October 30, 2024
概括
耐放射性抗性甲状腺癌 (RAI-RTCs) 的结果很差. 包括激酶抑制剂在内的向疗法在恢复放射性吸收和改善这些晚期分化甲状腺癌的治疗方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 内分泌学 在内分泌学.
背景情况:
- 分化甲状腺癌 (DTC) 是最常见的甲状腺瘤.
- 标准治疗 (手术,放射性治疗) 对大多数DTC有效.
- 放射性耐火DTCs (RAI-RTCs) 显示放射性吸收减少,导致预后较差.
研究的目的:
- 审查驱动RAI-耐火分化甲状腺癌 (RAI-RTCs) 的分子机制.
- 讨论RAI-RTCs当前和新兴的向疗法.
- 要突出在RAI-RTC中恢复放射性吸收的潜力.
主要方法:
- 关于DTCs,RAI-refractoriness和向疗法的最新科学文献的审查.
- 对涉及RAI-RTCs的遗传突变 (RTK,RAS,BRAF,TERTp) 和信号通路 (MAPK,PI3K) 的分析.
- 对全身治疗和新治疗策略的临床试验数据的检查.
主要成果:
- 遗传变化导致脱差和/合载体 (NIS) 功能障碍,导致RAI-折射性.
- 多酶抑制剂 (伦瓦提尼布,索拉费尼布,卡博赞提尼布) 是已确立的RAI-RTCs治疗方法.
- 选择性激酶抑制剂 (BRAF,MEK,mTOR) 在临床试验中显示出恢复RAI吸收的潜力.
结论:
- 针对性疗法为管理RAI-RTC提供了一个有希望的方法.
- 通过选择性激酶抑制恢复RAI吸收是一个活跃的研究领域.
- 通过大规模随机对照试验进行进一步验证对于推进治疗策略至关重要.
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