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胃肠道疾病和冠状动脉疾病之间的因果关系:双向的门德尔随机化研究
Zhuoxi Wang1, Jifang Ban1, Yabin Zhou2
1First Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Frontiers in endocrinology
|October 30, 2024
概括
对胃肠道疾病的遗传易感性可能会增加冠状动脉疾病 (CAD) 和心力衰竭 (HF) 的风险. 这凸显了在患有胃肠道疾病的个体中预防CAD的重要性.
科学领域:
- 遗传学 遗传学 是一个
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
背景情况:
- 冠状动脉疾病 (CAD) 是全球主要的死亡原因.
- 胃肠道疾病 (GDs) 越来越多地被认为是导致CAD的潜在原因.
- GDs和CAD之间的因果关系需要进一步调查.
研究的目的:
- 调查各种胃肠道疾病 (GDs) 和冠状动脉疾病 (CAD) 之间的潜在因果关系.
- 探索GD和心力衰竭 (HF) 之间的关联.
- 要确定这些关系是否是双向的.
主要方法:
- 使用两个样本的门德尔随机化 (MR) 分析.
- 从GWAS数据集中使用22个GD的单核酸多态 (SNPs) 作为仪器变量.
- 使用来自英国生物银行,FinnGen和其他GWAS的数据进行了单变量MR (UVMR),多变量MR (MVMR) 和双向MR分析.
主要成果:
- 对胃食道逆流病的遗传责任与CAD和HF风险都有积极的关联.
- 对乳病的遗传责任与CAD和HF的风险增加有关,在MVMR后持续存在.
- 在CAD和腹腔疾病之间观察到相互因果关系.
结论:
- 对某些GD的遗传倾向可能会因果性地增加患CAD和HF的风险.
- 这些发现强调了在被诊断为GDs的患者中采取主动的CAD预防策略的重要性.
- 这项研究提供了特定胃肠道疾病和心血管疾病之间的遗传联系的证据.
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