使用碳糊电极修饰与离子液/Ni-Co层叠双氧化物纳米片的碳糊电极作为电压传感器测定甲基酸盐
Peyman Mohammadzadeh Jahani1, Fariba Garkani Nejad2, Reza Zaimbashi2
1School of Medicine, Bam University of Medical Sciences, Bam, Iran.
ADMET & DMPK
|October 30, 2024
概括
一个使用离子液体/Ni-Co层叠双氧化物纳米片的新型电化学传感器提供了对抗癌药物甲状腺酸盐 (MTX) 的敏感检测. 这种具有成本效益的方法对于治疗药物监测和临床诊断非常有价值.
科学领域:
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 甲基 (MTX) 是一种重要的抗癌药物.
- 过度使用MTX可能会导致严重的副作用.
- 对于MTX,敏感的确定方法是必不可少的.
研究的目的:
- 开发一种简单而敏感的电化学传感器,用于MTX测定.
- 为了利用离子液体 (IL) 和Ni-Co分层双氧化物 (Ni-Co-LDH) 纳米片用于传感器修改.
- 为了评估传感器的性能,用于MTX量化.
主要方法:
- 用IL/Ni-Co-LDH纳米片 (IL/Ni-Co-LDH/CPE) 修改的碳糊电极的制造.
- 使用循环电压测量,微分脉冲电压测量和时电压测量进行电化学表征.
- 在各种度中检测MTX的性能评估.
主要成果:
- IL/Ni-Co-LDH/CPE传感器对MTX度的线性反应显示为0.02至140.0μM.
- 实现了0.006μM的低检测极限.
- 在真实样本回收测试中,高精度被证明具有1.7%至3.7%之间的相对标准偏差.
结论:
- 开发的IL/Ni-Co-LDH/CPE传感器具有成本效益,并表现出卓越的性能.
- 该传感器适合对MTX的准确治疗药物监测.
- 这种方法对临床诊断具有前景.
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