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在没有糖尿病视网膜病变的2型糖尿病患者中视网膜和胆道血管化参数
Artur Małyszczak1, Joanna Wiktoria Przeździecka-Dołyk2, Urszula Szydełko-Paśko1
1Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Dolnoslaskie, Poland.
Clinical ophthalmology (Auckland, N.Z.)
|October 30, 2024
概括
没有视网膜病变的2型糖尿病 (DM) 显著降低了视网膜表面毛细血管 (SCP) 和胆道血管度指数 (CVI). 这些血管变化独立于年龄和性别,突出显示早期糖尿病并发症.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 2型糖尿病 (DM) 是一种系统性疾病,影响多个器官,包括眼睛.
- 糖尿病视网膜病变 (DR) 是一种常见的并发症,但在临床DR明显之前,可能会发生早期血管变化.
- 视网膜和冠状腺血管化的评估可以提供有关糖尿病早期微血管损伤的见解.
研究的目的:
- 评估2型DM但没有DR患者的视网膜和胆道血管化参数.
- 为了比较2型DM患者和健康对照之间的这些参数.
- 确定影响早期糖尿病血管变化的因素.
主要方法:
- 74名患者 (40名患有DM,34名对照) 接受了光学一致性断层扫描血管图 (OCTA).
- 分析了3x3mm的斑点扫描,以检测表面和深层毛细管的血管密度 (SCP和DCP),胸腔血管度指数 (CVI) 和胸腔厚度 (CT).
- 进行了根据年龄和性别调整的多变量回归分析.
主要成果:
- 糖尿病患者在上部和鼻腔段显示SCP降低,在所有测量段显著降低CVI.
- 冠状腺厚度 (CT) 在DM组中中部和下部增加.
- 降低中央CVI与DM,较低的SCP和较大的状血管区域有关;增加的中央CT与较高的SCP和男性性别有关.
结论:
- 没有DR的糖尿病患者表现出减少的SCP和CVI,表明早期的微血管变化.
- CVI受到DM和SCP的显著影响,不论年龄和性别.
- 中央CT受SCP和性别的影响,而不仅仅是糖尿病的存在.
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