内微生物可以影响肝细胞癌的进展
Bao-Qun Liu1, Yi Bai2, Da-Peng Chen1
1First Central Clinical College, Tianjin Medical University, Tianjin 300070, China.
World journal of gastrointestinal oncology
|October 30, 2024
概括
内微生物不同于肝细胞癌 (HCC). 菌及其代谢物酸通过影响NF-κB通路来抑制HCC细胞的生长和迁移.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 内微生物与肝细胞癌 (HCC) 的发展有关,但它们在瘤进展中的确切作用尚未完全理解.
- 需要进一步的研究来阐明这些微生物在HCC瘤微环境中的功能.
研究的目的:
- 研究HCC组织中的微生物组成,并评估Propionibacterium对HCC进展的影响.
- 探索 Propionibacterium 影响 HCC 细胞行为和信号通路的机制.
主要方法:
- 光在位杂交 (FISH) 和16SrRNA测序被用于分析HCC和相邻组织中的微生物群落.
- 使用HCC细胞的体外共培实验和体内模型 (正极体和皮下异种移植) 用于评估Propionibacterium和酸 (PA) 的作用.
主要成果:
- 在HCC和周组织之间观察到微生物分布和丰度的显著差异,Propionibacterium有显著差异.
- 在实验室中,Propionibacterium及其代谢物PA对HCC细胞增殖和迁移表现出抑制作用.
- 暴露于Propionibacterium后,NF-κB通路相关蛋白质的表达在HCC细胞中减少.
结论:
- 独特的微生物特征标志着HCC和正常的肝脏组织,突出显示了与该疾病相关的功能失调.
- 在HCC中发现的一种PA产生细菌Propionibacterium通过调节NF-κB信号通路并影响瘤细胞行为的方式来影响HCC的进展.
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