用皮肤基质治疗儿科深度部分厚度烧伤
Katherine C Bergus1, Dana M Schwartz1, Kelli N Patterson1
1Nationwide Children's Hospital, Burn Center, 700 Children's Drive, Columbus, Ohio.
Eplasty
|October 30, 2024
概括
皮肤基板 (DS) 在儿科深度部分厚度烧伤中促进愈合,大多数患者在没有自移植的情况下愈合. 与自移植相比,DS的应用导致伤口感染和痕收缩较少.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 儿科手术 儿科手术
背景情况:
- 皮肤基板 (DS) 被用作皮肤替代品,以帮助烧伤患者的伤口愈合.
- 它们可以作为最终治疗或为随后的移植准备伤床.
- 这项研究的重点是描述DS应用后的伤口愈合结果在患有深度部分厚度烧伤的儿科患者中.
研究的目的:
- 评估皮肤基质 (DS) 促进伤口愈合的疗效,对于患有深度部分厚度烧伤的儿科患者.
- 为了比较单独的DS治疗与随后自移植的DS之间的并发症率.
主要方法:
- 从2015年至2023年对患有DS (胎牛皮肤修复支架) 的儿科患者 (<18岁) 的回顾性评估.
- 收集的数据包括人口统计,烧伤细节,手术程序和术后并发症.
- 使用 χ2 和费舍尔精确测试进行统计比较.
主要成果:
- 在205名患者中,84.4%仅用DS治愈;15.6%需要自移植.
- 与需要自移植的患者相比,仅用DS治疗的患者的伤口感染率 (2.9%vs12.5%) 和痕收缩率 (5.8%vs15.6%) 显著降低.
- 对于需要自移植的患者,移植区域的中位数占原始伤口表面的50%.
结论:
- 皮肤基板治疗单独对儿科深度部分厚度烧伤非常有效,可以实现高愈合率和低并发症.
- 虽然有些患者可能需要自移植,但DS应用是一个可行的策略.
- 发现有助于外科医生为儿童烧伤的DS应用程序的结果咨询家庭.
相关概念视频
Burn Injuries
2.4K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.4K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K


