废水微生物组与人口吸烟率之间的关联使用基于废水的流行病学来确定
Jiangping Wu1, Shuxin Zhang1, Yan Chen1
1School of Civil, Mining, Environmental and Architectural Engineering, University of Wollongong, Wollongong 2522, Australia.
Environment & health (Washington, D.C.)
|October 30, 2024
概括
废水分析揭示了与人口吸烟率相关的特定微生物生物标志物. 这种基于废水的流行病学方法可以监测长期的吸烟行为及其肠道微生物群的影响.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生监督是对公共卫生的监督.
- 转基因组学是指转基因组学.
背景情况:
- 烟草使用通过改变口腔,呼吸道和肠道微生物群,显著影响人类健康.
- 了解这些微生物组变化对于公共卫生倡议至关重要.
- 基于废水的流行病学提供了一种非侵入性的方法来评估人口层面的行为.
研究的目的:
- 调查家庭废水中的人类微生物组与人口吸烟率之间的联系.
- 为了确定废水中的微生物生物标志物,表明吸烟的流行.
- 探索吸烟对肠道微生物组的组成和功能的影响.
主要方法:
- 废水样本从不同吸烟率的流域收集.
- 使用元基因组测序来分析微生物群落.
- 一个生物标志物发现算法,包括线性判别分析效果大小 (LEfSe),确定了潜在的微生物生物标志物.
主要成果:
- 特定的微生物包括*Neisseria*,*Desulfovibrio*和*Enterococcus*被确定为潜在的吸烟生物标志物.
- 更高的吸烟率与增加的病原体如Neisseria,Eikenella和Haemophilus的丰富性相关.
- 吸烟与信息处理中的微生物基因表达上调和氨基酸,脂质和银河糖的代谢下调有关.
结论:
- 废水中确定的微生物生物标志物反映了长期吸烟导致的肠道微生物组变化.
- 基于废水的流行病学是监测人口吸烟行为的有希望的工具.
- 这些发现有助于理解微生物组在吸烟相关健康影响中的作用.
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