血液中的COVID-19微血块的3D全息图谱绘制,以评估疾病的严重程度
Talia Bergaglio1,2, Olena Synhaivska1, Peter Niraj Nirmalraj1
1Transport at Nanoscale Interfaces Laboratory, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf CH-8600, Switzerland.
Chemical & biomedical imaging
|October 30, 2024
概括
研究人员使用3D数字全息显微镜识别和量化COVID-19患者的微结块. 这种方法揭示了长期COVID的潜在指标,将其与健康个体区分开来.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19的长期健康影响,包括心血管和认知问题,在康复后仍然存在.
- 微米大小的血块和过度活化的血小板是长期COVID的潜在生物标志物.
- 准确的检测方法对于理解和管理长期COVID至关重要.
研究的目的:
- 在COVID-19患者血中可视化和量化微结块结构,使用无标签的3D数字全息断层显微镜 (DHTM).
- 为了区分微小血栓和血小板聚合物与健康对照.
- 建立一个快速的,临床上适用的成像工作流程,用于微结块分析.
主要方法:
- 使用3D数字全息断层显微镜 (DHTM) 进行无标签的等离子体样本成像.
- 使用3D折射率 (RI) 断层扫描量化微结块大小,干质量和流行率.
- 开发了一个分析工作流程,用于微结块复合材料,富含纤维素的微结块和血小板聚合物的参数差异化.
主要成果:
- 在COVID-19患者的血中成功地解决和量化了微结块结构.
- 在COVID-19患者和健康对照者之间,微小血栓和血小板总流行率有显著差异.
- 建立了一个工作流程,从样本准备到结果的交付时间为2小时,适合临床环境.
结论:
- DHTM是一种有效的无标签技术,用于表征与COVID-19相关的微结块.
- 微血栓和血小板聚合物在COVID-19患者中更为普遍,这表明它们在长期COVID中发挥了作用.
- 开发的快速成像和分析工作流程有可能用于诊断和监测长期COVID的临床应用.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...