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在远距离二头肌修复后的异型骨化 (HO) 预防
Udit Dave1, Jayanth Mosalakanti1, Pavan Guduri1
1School of Medicine, Tulane University, New Orleans, LA, USA.
JSES reviews, reports, and techniques
|October 30, 2024
概括
远距离双肩修复后的异型骨化 (HO) 可能会被印梅他辛减少,但由于有效性有限和潜在风险,不建议常规使用. 进一步的研究应该探索其他NSAID或没有预防.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 异型骨化 (HO) 是远距离二头肌修复的并发症,影响四肢功能和患者的结果.
- 目前的预防方法包括非类固醇抗炎药物 (NSAID) 和放射治疗.
研究的目的:
- 系统地审查文献并确定远距离双肩修复后HO预防的有效手段.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在PubMed,Embase和Cochrane图书馆搜索1998年以后发表的研究.
- 包括前性随机对照试验和回顾性病例控制研究,比较HO预防与不预防.
主要成果:
- 四项研究符合纳入标准,所有这些研究都评估了印梅他辛;其中一项还评估了梅洛西卡姆.
- 两项研究支持Indomethacin用于HO预防,一项没有,一项发现Indomethacin和Meloxicam同样有效.
- 没有研究分析了HO预防的放射治疗.
结论:
- 由于有效性有限和潜在的风险,远距离双肩修复后用于HO预防的常规使用印莫他辛是不必要的.
- 未来的研究应该调查其他NSAIDs (例如,梅洛西卡姆) 或在单切口和双切口修复方面缺乏预防.
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