乙酸性食道炎的药理疗法:有效的,可能有效的和失败的药物
Alain M Schoepfer1, Ekaterina Safroneeva2
1Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Inflammatory intestinal diseases
|October 30, 2024
概括
性食道炎 (EOE) 的治疗包括药物,饮食和扩张. 本综述详细介绍了药理选择,包括已批准的治疗方法,如口腔 dispersible budesonide 和 Dupilumab,并讨论了它们的疗效和对 EoE 管理的局限性.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性食道炎 (EoE) 是一种由食物过敏原驱动的慢性食道疾病,如果不治疗,会导致食道重塑.
- 有效管理EoE至关重要,目前的策略包括药理疗法,饮食改变和食道扩张.
- 本综述特别探讨了EoE可用的基于药物的治疗选择.
研究的目的:
- 审查和总结当前对埃索诺菲尔性食道炎 (EoE) 的药理疗法的情况.
- 讨论各种用于EdE管理的药物的疗效和监管状况.
- 突出EdE药物治疗中的局限性和未来方向.
主要方法:
- 对EoE的药理疗法的文献综述.
- 对已批准的治疗方法的分析,包括可口 dispersible budesonide 和 Dupilumab.
- 对非标签使用和非推剂的证据的评估.
主要成果:
- 口中可分散的布德索尼德 (Jorveza®,Eohilia®) 和Dupilumab是已批准的疗法,在EoE治疗中证明了有效性.
- 研究人员发起的研究表明,针对性的布德尼德和流动松配方的疗效.
- 质子抑制剂 (PPI) 对EoE的疗效有限且不一致.
- 一些药物,包括全身类固醇和某些生物药物,由于缺乏疗效或安全问题,不建议使用.
结论:
- 对EoE的药理选择正在扩大,局部皮质类固醇和向生物药物显示出希望.
- 关于当前EoE疗法的有效性和安全性的长期数据仍然有限.
- 需要进一步的研究和合作努力,以优化对EoE患者的治疗策略.
相关概念视频
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
240
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
240
01:19Antiasthma Drugs: Leukotriene Modifiers
246
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
246
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
223
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
223
01:26Peptic Ulcer Disease IV: Management
74
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
74
01:17Drugs Used in Lower Respiratory Disorders: Overview
353
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
353
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
55
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
55