心血管疾病中的大脑功能改变和认知表现:对fMRI研究的系统审查
Syeda Humayra1, Noorazrul Yahya2, Chai Jia Ning1,3
1Makmal Pemprosesan Imej Kefungsian (Functional Image Processing Laboratory), Department of Radiology, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Frontiers in neurology
|October 30, 2024
概括
心血管疾病 (CVD) 与认知能力下降和大脑功能受损有关. 本综述强调了心血管疾病如何影响大脑网络连接,影响患者的认知表现和任务执行.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 医疗成像医学成像
背景情况:
- 心血管疾病 (CVD) 可以导致大脑低效,但它们对大脑功能和认知的影响还未得到充分研究.
- 功能磁共振成像 (fMRI) 是评估这些大脑变化的关键工具.
研究的目的:
- 系统地审查和综合fMRI发现 (休息状态和基于任务) 和心血管疾病患者的认知表现.
- 探索心血管疾病,大脑功能改变和认知结果之间的关系.
主要方法:
- 在主要数据库 (ScienceDirect,PubMed,Web of Science,ClinicalTrials.gov) 进行了系统的文献搜索,遵循PRISMA协议.
- 经过全文查和质量评估,包括了10项符合条件的研究,涉及336名心血管疾病患者.
主要成果:
- 患有心血管疾病的患者表现出认知能力下降 (MMSE/MoCA得分较低) 和任务表现较差 (例如,双背任务).
- 在补充运动区域观察到大脑活动受损,与射出分数有关.
- 减少默认模式网络抑制,较低的区域同质性和功能连接性下降与心血管疾病和认知缺陷有关.
结论:
- 心血管疾病显著改变大脑网络连接,导致认知障碍和任务性能降低.
- 未来的研究应该专注于在心血管疾病患者的成像研究中使用更均的人口统计数据.
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