患有Helicobacter pylori感染的患者中与代谢功能障碍相关的脂肪肝炎的患病率和风险因素:基于人口的研究
Rashid Abdel-Razeq1, Lynn Bitar2, Elio R Bitar3
1Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44111, United States. abdelr3@ccf.org.
World journal of hepatology
|October 30, 2024
概括
杆菌感染显著增加了患有代谢功能障碍相关脂肪肝炎 (MASH) 的风险. 这项大型研究发现,H. pylori是MASH的独立风险因素,突出了肠道健康和肝脏疾病之间的关键联系.
科学领域:
- 胃肠病学和肝病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 杆菌 (H. pylori) 感染是各种胃肠道疾病的已知危险因素,包括胃炎和胃癌.
- 有限的研究存在于H. pylori感染和代谢功能障碍相关的脂肪肝炎 (MASH) 之间的关联.
- 这项研究解决了证据的稀缺性,通过调查有H. pylori感染史的患者中MASH的独立风险.
研究的目的:
- 为了确定被诊断为H. pylori感染的个体中发展MASH的风险.
- 分析H. pylori感染和MASH之间的关联,控制潜在的混因素.
主要方法:
- 利用一个大型的,多中心的美国数据库 (1999-2022),涵盖360多家医院.
- 采用多变量回归分析来评估MASH风险,调整主要混因素,如肥胖,2型糖尿病,高血压,脂质失调和男性性别.
- 在最终分析中包括了69232620个人的大量样本大小.
主要成果:
- H. pylori 感染与患MASH的几率增加了2.51倍 (95% CI:2.31-2.73).
- 重要MASH风险因素包括糖尿病 (OR: 3.55),肥胖 (OR: 5.93),男性性别 (OR: 1.49) 和高脂血症 (OR: 2.43).
- 与对照组相比,MASH的患病率在患有高脂血症,高血压,糖尿病和肥胖症的患者中较高.
结论:
- 这项基于人口的广泛研究证实了H. pylori感染与MASH的患病率增加之间存在显著联系.
- 杆菌感染成为MASH的独立风险因素,即使考虑到其他已确定的风险因素.
- 这些发现强调了在MASH的管理和预防中考虑H. pylori状态的重要性.
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