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Updated: May 2, 2026

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SGLT1抑制对脆弱性和肉症的影响:一个调解门德尔随机化研究

Bang-Bang Huang1,2,3,4,5, Yu-Jie Zhang6, Guang-Feng Ruan7

  • 1Department of Geriatrics, First Affiliated Hospital of Fujian Medical University, Institute of Neuroscience, Fujian Medical University, Fuzhou, China.

Journal of cachexia, sarcopenia and muscle
|October 30, 2024
PubMed
概括

抑制-葡萄糖携带体1 (SGLT1) 可能会减少老年人的脆弱性和肉症. 这种效应部分由胰岛素耐药性介导,涉及各种蛋白质和代谢物.

关键词:
门德尔的随机化抑制了SGLT1的发生.脆弱 脆弱 脆弱 脆弱 脆弱这种类型的麻症是sarcopenia.

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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