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在周围膀癌免疫格局中改变了免疫类型表达
Nathan J Mackenzie1,2, Kate Zimmermann1,3,4, Clarissa Nicholls1,2
1Queensland University of Technology (QUT), School of Biomedical Sciences at Translational Research Institute (TRI), Brisbane, QLD, Australia.
膀癌 (BC) 患者的外周血液免疫细胞表现出改变的形状,具有较低的B细胞和较高的T细胞. 像PD-1这样的免疫检查点标记物升高,可能预测BC进展并指导个性化治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 针对免疫系统的膀癌 (BC) 治疗只对一小部分患者有益.
- 生物标志物是预测BC进展和对治疗的反应所需的.
- 周围血液的免疫特征可能为BC提供了洞察力.
研究的目的:
- 调查周围血液免疫子集,免疫检查点标记物和BC的临床病理特征之间的关联.
- 为了确定BC进展和治疗反应的潜在生物标志物.
主要方法:
- 来自23名BC患者和9名对照者的外周血液单核细胞的流细胞计分析.
- 使用21参数面板评估T,B,NK和髓状细胞种群.
- 评估免疫检查点标记者编程细胞死亡蛋白1 (PD-1) 和T细胞免疫球蛋白和含有-3 (TIM-3) 的粘素域.
主要成果:
- 与对照组相比,BC患者的循环CD19+B细胞较低,CD4+CD8+T细胞增加.
- 在BC患者的外周免疫细胞中增加PD-1和TIM-3表达.
- 在T细胞和髓状细胞上增加PD-1表达与肌肉侵入性BC相关.
- 与瘤阶段相关的T,B和髓状细胞上的PD-1表达,这表明免疫疲劳预测了进展.
结论:
- 周围血液免疫类型在BC患者中发生变化.
- 周围血液中免疫检查点标志物表达的升高可能预测BC进展.
- 了解这些免疫变化可以帮助开发个性化BC治疗的诊断/预后指标.
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