具有pH和葡萄糖双响应的基酸水凝用于智能胰岛素输送
Keke Yang1, Hou Bo1, Dewei Ma1
1Research Institute for Biomaterials, Tech Institute for Advanced Materials Bioinspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, China. siyuan.chen@njtech.edu.cn.
这项研究开发了一种双响应的水凝,通过克服酸 (PBA) 的局限性来实现智能胰岛素输送. 新型水凝表现出增强的葡萄糖敏感性和pH响应性,改善治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 酸 (PBA) 对于对葡萄糖有反应的水凝至关重要,但由于其高的pKa,具有局限性.
- 生理条件对PBA的葡萄糖结合亲和力构成挑战,阻碍了智能胰岛素输送应用.
研究的目的:
- 开发一种双响应的水凝系统,克服PBA高pKa的局限性,提高葡萄糖敏感性.
- 创建一个智能胰岛素输送系统,提高对pH和葡萄糖水平的响应能力.
主要方法:
- 合成了新型的聚-L-氨酸异甲胺 (PLP) 聚合物与3-氨基基酸 (3-PBA) 相结合.
- 通过将PLP-PBA聚合物与L-氨酸甲基 (LME) 交叉连接而产生双反应的LME-(PLP-PBA) 水凝.
- 通过不同程度的PBA接种和交叉链接来研究水凝的特性,包括风湿学,胀率和胰岛素释放.
主要成果:
- 根据PBA接种和交叉连接比率,可以调整水凝的特性,如质和胀.
- 增加的pH和葡萄糖度导致水凝毛孔大小增加,促进胰岛素的释放.
- 在生理条件下,最佳的水凝配方证明了急性pH和葡萄糖对胰岛素释放的反应性.
结论:
- 开发的双响应水凝提供了一种可行的策略,以解决PBA的高pKa问题.
- 这种创新的水凝系统为先进的智能胰岛素输送应用提供了一个有前途的平台.
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