精神病症状尺寸与双胞胎和一般临床样本中的临床和发育变量之间的关联
Alastair G Cardno1, Judith Allardyce2,3, Steven C Bakker4
1Division of Psychological and Social Medicine, University of Leeds, Leeds, UK.
The British journal of psychiatry : the journal of mental science
|October 30, 2024
概括
精神病症状尺寸显示出与临床和发育因素的明显关联. 特别是混乱的症状,表明了可能与先发性智力相关的重大家族影响.
科学领域:
- 精神病学和临床心理学
- 行为遗传学 行为遗传学
背景情况:
- 精神病症状的尺寸 (积极,消极,无组织) 与临床和发育变量有关.
- 不一致的定义和对某些变量的有限研究使解释变得复杂.
研究的目的:
- 检查精神病症状尺寸和临床/发育变量之间的关联.
- 通过在多个样本中使用一致的定义来调查这些症状维度的家族聚合.
主要方法:
- 分析了两个双胞胎和两个一般精神病样本 (n=875名试验者).
- 使用的操作标准检查清单,用于症状尺寸和其他变量.
- 在通用线性混合模型中使用后勤回归,并分析了单胞胎双胞胎对中的相关性.
主要成果:
- 所有的症状维度都与不良的病前社会适应,从未结婚/同居,早期发病年龄和慢性病程有关.
- 与少数民族和大麻使用相关的积极维度;与男性性别相关的负面维度.
- 无组织的维度与逐渐发病,较低的先发病智商和显著的家族相关性有关,包括双胞胎对.
结论:
- 证实了跨维度的共同关联,并加强了明显联系的证据.
- 与少数民族身份相关的积极症状;与男性性别相关的负面症状.
- 混乱的症状显示出大量的家族影响,可能与病前智商影响重叠.
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