菌体多样性在一个健康中
Hannah V Pye1,2, Revathy Krishnamurthi1,2, Ryan Cook1,2
1Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.
Essays in biochemistry
|October 30, 2024
概括
杀死细菌的病毒 - - 菌体 (菌体) 对One Health至关重要. 目前的应用在很大程度上有利于Caudoviricetes,不充分利用各种菌体类型,并限制它们在打击抗菌素耐药性的潜力.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 一个健康倡议一项健康倡议.
背景情况:
- 一个健康整合了人类,动物和环境健康研究.
- 菌体 (菌体) 是细菌病毒,在医学和生物控制中具有潜在的应用.
- 菌体治疗和环境生物控制是实现"一个健康"目标的关键.
研究的目的:
- 评估过去五年在One Health应用中使用的菌体的多样性.
- 在全球菌体多样性中对当前的菌体使用进行上下文化.
- 识别当前的菌体隔离和应用方法中的局限性和偏差.
主要方法:
- 关于菌体在人类,动物和环境健康中的应用在过去5年的科学文献的综述.
- 在One Health应用程序中对菌体多样性的比较分析与整体测序菌体多样性的比较分析.
- 鉴定用于生物控制和治疗的菌体类别和类型.
主要成果:
- 在One Health中应用的菌体中有98%属于Caudoviricetes类,略高于一般菌体测序数据中发现的85%.
- 只有三种RNA菌体在商业上用于环境生物控制或人体治疗.
- 在目前的应用中,非Caudoviricetes菌体 (例如ssDNA,RNA菌体) 的显著不足.
结论:
- 在One Health中使用的菌体的多样性是有限的,主要是由于隔离和选择方法的偏差.
- 扩大各种菌体类型的使用,包括ssDNA和RNA菌体,对于实现它们的全部潜力至关重要.
- 需要对菌体基因组学和新培养技术进行进一步的研究,以充分利用菌体多样性的全部潜力,以实现"一个健康"目标和减少抗菌素耐药性.
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