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Updated: May 10, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
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Published on: January 25, 2017

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用诺金记者鼠标揭示IFN-β表达的调节和动态

Nikhil J Parekh1, Damion Winship1, Erik Van Dis1

  • 1Department of Immunology, University of Washington School of Medicine, Seattle, WA.

Journal of immunology (Baltimore, Md. : 1950)
|October 30, 2024
PubMed
概括

研究人员开发了一种新的记者小鼠模型来追踪表达干扰素β (IFN-β) 的细胞. 这个工具有助于研究IFN-β.

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NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The heterodimer of NF-κB...
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Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...