Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sample Size Calculation01:19

Sample Size Calculation

3.2K
Knowledge of the sample size is the first requirement to conduct random sampling or an experiment. The sample size is the total number of units, observations, or groups (in some cases) used to get the data to estimate a population parameter. As the name suggests, the sample size is that of the sample drawn from the population and differs from the population size.
The sample size for the given experiment or sampling effort is fundamental to any study design. Sample size decides the number of...
3.2K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

121
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
121
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

148
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
148
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

237
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
237
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Sampling Plans01:23

Sampling Plans

169
Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
169

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nipocalimab for the treatment of moderate-to-severe Sjögren's disease: a plain language summary of the DAHLIAS study.

Expert review of clinical immunology·2026
Same author

Efficacy and safety of nipocalimab in patients with moderate-to-severe Sjögren's disease (DAHLIAS): a randomised, phase 2, placebo-controlled, double-blind trial.

Lancet (London, England)·2025
Same author

Navigating the Future: Considerations for use of Continuous Glucose Monitoring in Diabetes Trials.

Therapeutic innovation & regulatory science·2025
Same author

Application of Bayesian Borrowing Methods in Clinical Trials for Children with Type II Diabetes Mellitus.

Therapeutic innovation & regulatory science·2025
Same author

Application of Bayesian statistics to support approval of intravenous belimumab in children with systemic lupus erythematosus in the United States.

Lupus·2025
Same author

Bayesian Hierarchical Models for Subgroup Analysis.

Pharmaceutical statistics·2024

相关实验视频

Updated: Jun 9, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.0K

在2型糖尿病的临床试验的第三阶段优化样本大小的确定.

Alexander C Cambon1, James Travis1, Liping Sun1

  • 1FDA Center for Drug Evaluation and Research, Office of Translational Science, Office of Biostatistics, Silver Spring, Maryland, USA.

Pharmaceutical statistics
|October 30, 2024
PubMed
概括

在成人2型糖尿病临床试验中,准确的差异估计可以在不影响有效性的情况下减少样本大小. 这种优化有助于未来的内分泌学研究,并加快试验结果.

关键词:
糖尿病 糖尿病患者 糖尿病患者样本大小估计的估计.差异差异是指差异的差异.

更多相关视频

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.6K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

200

相关实验视频

Last Updated: Jun 9, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.0K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.6K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

200

科学领域:

  • 临床试验 临床试验
  • 内分泌学 在内分泌学.
  • 糖尿病研究 糖尿病研究

背景情况:

  • 准确的受试者水平差异估计对于确定临床试验中适当的样本大小至关重要.
  • 评估过去的成人2型糖尿病研究将为未来的样本大小要求提供信息.
  • 美国食品和药物管理局 (FDA) 数据库为此类评估提供了有价值的数据.

研究的目的:

  • 在已完成的成人2型糖尿病临床试验中评估差异估计的准确性.
  • 根据历史数据,根据未来研究的样本大小要求提供信息.
  • 调查共变量对剩余标准偏差和样本大小重新估计的影响.

主要方法:

  • 对26项提交给FDA (2013-2017) 的3期随机成年2型糖尿病研究的分析.
  • 从基线到6个月,对糖化血红蛋白 (HbA1c) 的变化对象水平变异的估计.
  • 对9项额外研究的审查,以评估对剩余标准偏差和样本大小的共变量影响.

主要成果:

  • 对于成人2型糖尿病药物试验,减少样本大小是可行的,而不会影响疗效结果的有效性.
  • 来自已完成的研究的差异估计可以指导更有效的样本大小计算.
  • 临床上有意义的共变量可以影响剩余标准偏差和样本大小的重新估计.

结论:

  • 优化样本大小可用于成人2型糖尿病临床试验.
  • 这种优化可以缩短招聘时间,加快研究成果的交付.
  • 这些发现为设计未来内分泌学和糖尿病临床试验提供了宝贵的见解.