相关实验视频
Updated: Jun 9, 2025

20:16
Detecting Anastasis In Vivo by CaspaseTracker Biosensor
Published on: February 1, 2018
9.2K
怀孕期间的癌症化疗和不良儿科结果:基于人口的队列研究
Amy Metcalfe1,2,3, Zoe F Cairncross1, Carly A McMorris4
1Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB, Canada.
Journal of the National Cancer Institute
|October 30, 2024
概括
怀孕期间的化疗与严重的新生儿风险增加有关,主要是由于早产,而不是直接的药物影响. 大多数儿童经历了有利的长期结果,尽管在子宫内化疗暴露.
科学领域:
- 产科和妇科 产科和妇科
- 儿科瘤学 儿科瘤学
- 新生儿科学 新生儿科学
背景情况:
- 在怀孕期间,化疗的使用往往会延迟.
- 过早分娩是癌症妊娠中常见的并发症.
- 宫内化疗暴露与早产对儿科结局的直接影响尚不清楚.
研究的目的:
- 调查怀孕期间化疗暴露与儿科结果之间的关联.
- 确定早产是否调解了产前化疗和儿科不良结果之间的关系.
主要方法:
- 利用加拿大癌症登记册和行政数据 (2003-2017年).
- 确定了1150例患有癌症的怀孕;142例接受化疗.
- 分析了重症新生儿发病率和死亡率 (SNM-M),神经发育障碍 (NDD) 和复杂慢性疾病 (PCCC),使用修改的Poisson和Cox回归模型.
- 用调解分析来评估早产的作用.
主要成果:
- 怀孕期间的化疗暴露与SNM-M (95% CI: 1.13-2.46) 的1.67倍风险增加有关.
- 在产前化疗和NDD (HR:0.93) 或PCCC (HR:0.96) 之间没有发现显著的关联.
- 在分别在<34周和<37周的分娩中,早产导致化学疗法和SNM-M之间的关联率为75.8%和100%.
结论:
- 大多数在子宫内接受化疗的儿童长期表现良好.
- 过早分娩是导致这一群体新生儿不良后果的重要因素.
- 这些发现表明,旨在减少早产的干预措施可能会减轻与产前化疗相关的风险.
相关概念视频
Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
175
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
175
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K

