患有急性胰腺炎的男性和女性之间心血管结果的差异
Manyun Tang1,2, Yuye Ning3, Jiaqi An4
1Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Polish archives of internal medicine
|October 30, 2024
概括
男性在急性胰腺炎 (AP) 后面临更高的心血管风险. 这项研究强调了男性患主要心血管和脑血管不良事件 (MACCE) 的发生率更高,这表明需要针对性别特定的护理策略.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 急性胰腺炎 (AP) 与心血管疾病 (CVD) 风险增加有关.
- 现有研究尚未澄清这种心血管疾病风险升高是否在性别之间存在差异.
研究的目的:
- 在急性胰腺炎后的患者中调查和比较长期心血管结果的性别特异性.
主要方法:
- 利用了来自英国生物库 (UK Biobank) 的数据,这是一个基于人口的大型队列.
- 定义主要心血管和脑血管不良事件 (MACCEs) 为全因死亡,心肌梗塞和中风.
- 采用考克斯回归和赢比率方法进行性别差异分析,调整为共变量.
主要成果:
- 1371名AP患者 (42.5%男性) 接受了平均13.9年的随访.
- 与女性 (9.8/1000人年) 相比,男性的MACCE发病率 (16.44/1000人年) 较高.
- 男人患MACCE的风险明显更高 (调整HR1.8),所有原因的死亡率 (调整HR1.49),心肌梗塞 (调整HR2.75),中风 (调整HR1.67).
结论:
- 与女性相比,男性经历了急性胰腺炎后的更多不良心血管结果.
- 研究结果表明,需要为AP患者制定和实施性别特定的治疗策略,以减轻心血管风险.
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