化消毒副产品的雌激素破坏性影响:全面的评估和比较
Xueyao Chen1, Yaoming Ge1, Wei Shi1
1State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, Jiangsu, China.
Environmental science & technology
|October 30, 2024
概括
某些饮用水消毒副产品 (DBPs) 破坏内分泌系统,即使在低水平. 化和多化DBPs表现出最强烈的效果,带来潜在的健康风险.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
背景情况:
- 饮用水中的化消毒副产品 (DBPs) 是一个越来越严重的健康问题.
- 目前尚不完全了解DBP的内分泌干扰潜力,这限制了风险评估.
- 数据有限阻碍了对DBP健康风险的全面评估.
研究的目的:
- 为了评估43个DBPs的雌激素-雄激素效应.
- 为了比较不同类型的DBP的内分泌干扰功效.
- 阐明DBP内分泌干扰背后的分子机制.
主要方法:
- 使用人类乳腺癌细胞系检测43个DBP的雌激素活性.
- 对DBP内分泌干扰作用的比较分析,结合了以前的研究数据.
- 分子对接模拟以调查DBP与雌激素受体的结合.
主要成果:
- 在43个测试的DBP中,有16个表现出雌激素,抗雌激素,安卓或抗雄激素作用.
- 观察到的效应发生在饮用水中常见的度下.
- 与其他DBPs相比,化和多化DBPs显示出更高的内分泌干扰功效.
- 内分泌干扰疗效排名:有的 > 的 > 的物种.
- 类DBP被确定为潜在的内分泌干扰化合物.
- 分子对接揭示了疏水,,素结合,和范德瓦尔斯力介导受体结合.
- 结合力和分子体积与雌激素-雄激素效应的大小相关.
结论:
- 在饮用水中发现的DBP可能具有显著的内分泌干扰活动.
- 化和多化DBPs是特别强大的内分泌干扰剂.
- 了解DBP受体相互作用对于评估与饮用水污染物相关的健康风险至关重要.
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