微乳液基凝的配方,用于增强局部给予非类固醇抗炎药物
Muhammad Yasir Siddique1, Ahmad Raza Ashraf2, Salah Uddin Khan3
1Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Langmuir : the ACS journal of surfaces and colloids
|October 30, 2024
概括
微乳化凝 (μEGs) 可改善非类固醇抗炎药物 (NSAIDs) 的局部输送,如二甲和纳素. 这些凝通过皮肤提供更慢,持续的药物释放,增强治疗潜力.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 口服非类固醇抗炎药物 (NSAIDs) 可以控制疼痛和炎症,但会引起胃肠道副作用.
- 通过微乳液 (μE) 的局部NSAID输送是有效的,但由于液体性质和皮肤保留不良而受到限制.
- 微乳化凝 (μEGs) 是为了克服μEs的局限性而开发的,用于增强局部药物输送.
研究的目的:
- 探索含有二甲 (DF-Na) 和纳素 (NP-Na) 的微乳化凝 (μEG).
- 调查通过皮肤提供更慢,更持续的局部NSAID的潜力.
- 评估发达的μEGs的物理化学特性和ex vivo皮肤透.
主要方法:
- 使用麻油,水,Tween-20,Span-20,poloxamer 407和DF-Na或NP-Na,制备μEG.
- 使用光学显微镜,动态光散射和电子显微镜对微观结构的描述.
- 在pH值为5.5和7.4的子皮肤上的ex vivo透研究,通过光光谱分析.
主要成果:
- μEGs 显示出稳定的纳米滴状结构 (∼35-60 nm) 并过渡到油在水系统.
- 在μEGs的疏水微环境中证实了药物封装.
- 与μEs相比,μEGs在pH 5.5下在8-10小时内对DF-Na (>99%) 和NP-Na (>89%) 的释放速度明显较慢.
结论:
- 开发的μEG显示了NSAIDs持续局部递送的潜力,减少了全身暴露和副作用.
- 高粘度的μEG对于局部药物递送应用是有效的,特别是在皮肤相关的pH值.
- 这种配方策略为口服NSAID和传统局部微乳液提供了改进的替代品.
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