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唐氏综合征的常见皮肤疾病:系统性审查
Megan Lam1, Justin Di Lu1, Levi Elhadad2
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
JMIR dermatology
|October 30, 2024
概括
患有唐氏综合征 (DS) 的人患皮肤病的患病率更高,包括亚托皮炎和性炎. 建议对这些皮肤疾病进行早期查,以改善DS患者的治疗.
科学领域:
- 皮肤病学 皮肤病学
- 遗传学 是一个遗传学.
- 系统审查是系统的审查.
背景情况:
- 唐氏综合征 (DS) 与各种健康问题有关,包括心血管,胃肠道和免疫系统异常.
- 在DS患者中观察到几种皮肤病症,如腹炎.
研究的目的:
- 系统地审查和描述唐氏综合征患者皮肤疾病的流行,临床表现和独特方面.
- 为了确定与DS相关的常见和不太常见的皮肤疾病.
主要方法:
- 在2020年12月14日之前对EMBASE,MEDLINE和Web of Science进行了全面的电子数据库搜索.
- 包括观察性研究和病例报告,详细介绍了DS患者的皮肤疾病.
- 专注于报告常见皮肤病的流行数据的研究.
主要成果:
- 该审查确定了40个观察性研究和99个案例报告.
- 在DS中常见报告的皮肤病症包括亚托皮性皮肤炎 (19.7%的患病率),乳头菌根症 (24.7%),和注射瘤 (21.2%).
- 其他值得注意的疾病包括腺炎, ichthyosis,牛皮,大发和白.
结论:
- 患有唐氏综合征的患者表现出各种皮肤疾病的患病率增加,特别是传染性,炎症性,自身免疫性和结缔组织疾病.
- 缺乏确定的指导方针,用于查,管理和治疗DS人口中的皮肤病.
- 建议在DS患者的早期诊断和治疗中进行常规皮肤学查.
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