补偿止痛大小可以提供关于膝关节骨关节炎患者内源性疼痛调节的额外信息吗? :一个实验性研究
Elin Johansson1,2,3, Sofie Puts1,4,5,6, David Rice7,8
1Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels.
The Clinical journal of pain
|October 30, 2024
概括
抵消疼痛缓解的大小与有条件疼痛调制 (CPM),第二疼痛的时间总和 (TSP) 或膝关节骨关节炎 (KOA) 疼痛严重程度无关. 这些发现表明,偏移止痛可能提供超越CPM和TSP的疼痛调节的独特见解.
科学领域:
- 疼痛研究 疼痛研究
- 神经科学是一个神经科学.
- 临床疼痛评估 临床疼痛评估
背景情况:
- 膝关节关节炎 (KOA) 是一种普遍存在的疾病,其特点是慢性疼痛.
- 了解内源性疼痛调节机制对于开发有效的疼痛管理策略至关重要.
- 补偿止痛,有条件疼痛调制 (CPM) 和第二疼痛的时间总和 (TSP) 是疼痛调制的心理物理措施.
研究的目的:
- 检查KOA患者的偏移止痛大小和对CPM,TSP和临床疼痛严重程度的反应能力之间的关系.
- 确定异位止痛是否与KOA.中的其他已确定的疼痛调节过程有关.
主要方法:
- 88名患有KOA的参与者接受了对偏移止痛,CPM和TSP的心理物理测试.
- 临床疼痛严重程度使用膝盖损伤和骨关节炎结局得分 (KOOS PAIN) 进行评估.
- 统计分析包括线性混合效应模型和斯皮尔曼部分相关性来评估关联.
主要成果:
- 所有心理物理测试都显示出明显的疼痛调节 (P <0.05).
- 补偿止痛大小与CPM,TSP或KOOS PAIN没有显著的相关性 (P ≥0.05).
- 观察到的最大部分相关性是 ρ = 0.21.21.
结论:
- 在患有KOA的个体中,抵消止痛与CPM,TSP或KOOS PAIN无关.
- 虽然临床转换是不确定的,但偏移性止痛可能会提供超出CPM和TSP的内源性疼痛调节的独特信息.
- 需要进一步的研究,包括病例控制研究,以澄清KOA中偏移止痛的作用.
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