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Updated: Jun 9, 2025

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Published on: November 28, 2014

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在类风湿性关节炎中,Granzyme B会分裂tenascin-C,释放其C端域

Alexandre Aubert1,2, Amy Liu1,2, Martin Kao1,2

  • 1International Collaboration on Repair Discoveries (ICORD) Centre, British Columbia Professional Firefighters' Burn and Wound Healing Group, Vancouver Coastal Health Research Institute, and.

JCI insight
|October 30, 2024
PubMed
概括

在类风湿性关节炎 (RA) 患者中,Granzyme B (GzmB) 分离了tenascin-C (TNC),产生了在突液中发现的碎片. 这种GzmB-TNC相互作用有助于RA关节炎症.

关键词:
这是一种自身免疫力.细胞外矩阵是细胞外矩阵.炎症 炎症是一种炎症.蛋白质酶是一种蛋白质酶.类风湿病学 类风湿病学

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