在实验室中,Morinda citrifolia提取物对八种致病性细菌物种的抗菌活性
Frederick Obeng-Boateng1, Stephen Wilson Kpordze1,2,3, Francis Addy1
1Faculty of Biosciences, Department of Biotechnology and Molecular Biology, University for Development Studies, Tamale, Ghana.
PloS one
|October 30, 2024
概括
莫林达叶 (Morinda citrifolia) 提取物显示出对各种病原体具有有前途的抗菌特性. 根提取物表现出最强烈的活性,特别是对抗Campylobacter spp.,强调其作为天然抗生素替代品的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 微生物学 微生物学
背景情况:
- 抗生素耐药性是一个日益严重的全球健康问题.
- 迫切需要新的抗菌化合物.
- 传统上,Morinda citrifolia (Noni) 是用于传染病的药物.
研究的目的:
- 为了研究Morinda citrifolia提取物的抗菌潜力.
- 评估从根,叶子和水果 (新鲜,干燥,发酵) 的提取物.
- 用不同的溶剂测试针对格拉姆阳性和格拉姆阴性细菌的疗效.
主要方法:
- 在体外抗菌试验中采用了阿加井扩散方法.
- 蒸水和乙醇 (60%,80%,100%) 被用于提取.
- 齐普罗夫洛克萨作为阳性对照,并进行统计分析 (ANOVA).
主要成果:
- 莫林达叶根提取物表现出最显著的抗菌活性.
- 较高的乙醇度 (100%) 产生了更大的抑制区域.
- 提取物对Campylobacter spp.,Enterococcus faecium和Bacillus cereus是最有效的.
结论:
- 莫林达叶 (Morinda citrifolia) 对一系列细菌表现出显著的抗菌潜力.
- 根和水果提取物,特别是含有较高乙醇度的,显示出有前途.
- 需要进一步研究Morinda citrifolia作为新型抗生素的来源.
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