阿托瓦斯塔丁在患有牙周炎的1型糖尿病大鼠中加速膜骨损失
Gisele Barreto Angelino1, Karysia Veras2, Delane Gondim Viana3
1Post-Graduate Program in Morphological Science, Federal University of Ceara, Fortaleza, Ceara, Brazil.
Brazilian dental journal
|October 30, 2024
概括
阿托瓦斯塔丁 (ATV) 在糖尿病大鼠中没有防止牙周骨损失和恶化骨损失. 此外,ATV还增加了血糖水平,这表明在不受控制的糖尿病中使用它应该谨慎.
科学领域:
- 牙周病学 牙周病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病增强了牙周骨损失.
- 阿托瓦斯塔丁 (ATV) 有抗炎和抗吸收作用,但可能会增加糖尿病风险.
- 需要研究ATV,糖尿病和牙周病之间的相互作用.
研究的目的:
- 评估阿托瓦斯塔丁 (ATV) 对患有试验性牙周炎和糖尿病 (DM) 的老鼠膜骨的影响.
主要方法:
- 72只Wistar大鼠被分为天真,实验性牙周炎 (EP),糖尿病 (DM) 和ATV DM组.
- 马尔代夫牙是由链接诱导的;牙周炎是由链接诱导的.
- 在ATV DM组中,每天都会口服ATV.
- 部经过宏观,微观图和显微镜分析.
主要成果:
- 糖尿病导致了显著的膜骨损失 (60%),骨体积和椎骨厚度降低,骨质细胞减少,骨质细胞和炎症增加.
- 在糖尿病老鼠中,ATV增加了21%的骨损失,并显著增加了血糖水平.
- 在患有牙周炎的糖尿病大鼠中,ATV没有预防骨损失或调节炎症.
结论:
- 在患有牙周炎的糖尿病大鼠中,阿托瓦斯塔丁在保护膜骨方面无效.
- 在不受控制的糖尿病病症中,系统使用阿托瓦斯塔丁需要仔细评估,因为它对骨和血糖控制有不良影响.
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