在艾滋病毒感染的老年人中,较低的T-CD4+ / CD8+淋巴细胞比率与认知障碍之间的关联
Carlos Alberto Ruiz-Manríquez1, José Alberto Avila-Funes2, Fátima Brañas3
1Geriatric Medicine Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14080, Tlalpan, Mexico City, Mexico.
European geriatric medicine
|October 30, 2024
概括
较低的CD4+/CD8+T细胞比率与艾滋病毒感染的老年人认知障碍有关. 这一发现突出了潜在的生物标志物,用于识别患有神经认知衰退风险的个体.
科学领域:
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 携带艾滋病毒的老年人患有认知障碍的风险增加.
- CD4+/CD8+ T细胞比率是免疫系统健康的指标.
研究的目的:
- 调查CD4+/CD8+T细胞比率与艾滋病毒感染的老年人认知障碍之间的关联.
主要方法:
- 一项横截面研究包括207名50岁以上的艾滋病毒感染成年人.
- 神经心理评估被用来诊断与艾滋病毒相关的神经认知障碍.
- 多变量逻辑回归分析了CD4+/CD8+T细胞比率三位数和认知障碍之间的关系.
主要成果:
- 66.2%的参与者患有某种形式的认知障碍,无症状神经认知障碍是最常见的.
- 最低的CD4+/CD8+T细胞比率三分之一 (<0.56) 独立与认知障碍相关 (OR 3.16).
结论:
- 较低的CD4+/CD8+T细胞比率与艾滋病毒感染的老年人认知障碍独立相关.
- 这个比率可以作为识别有风险的个体的一个因素.
- 认知查和可修改风险因素的管理至关重要.
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