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Updated: Jun 9, 2025

Inducible and Reversible Dominant-negative DN Protein Inhibition
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一个开创性的转录因子的药理学阻断

Katerina Cermakova1,2, H Courtney Hodges2,3,4

  • 1Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas.

Cancer research
|October 30, 2024
PubMed
概括

针对转录因子PU.1 (SPI1) 的新化合物改变了急性髓性白血病中的基因组结合. 这一策略将PU.1重定向到促销者,为血液恶性瘤提供了一种新的方法.

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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