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相关概念视频

Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

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The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
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The Mammary Glands01:12

The Mammary Glands

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The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
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G-protein Coupled Receptors01:21

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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The Pituitary Gland01:17

The Pituitary Gland

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The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
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Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

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Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
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The Pineal Gland01:02

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The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
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Evaluation of Mammary Gland Development and Function in Mouse Models
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益生菌:结构,受体和功能

Fanny Chasseloup1, Valérie Bernard2,3, Philippe Chanson4

  • 1Physiologie et Physiopathologie Endocriniennes, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l'Hypophyse (HYPO), Hôpital Bicêtre, INSERM, Université Paris-Saclay, AP-HP, Le Kremlin-Bicêtre, 94275, France.

Reviews in endocrine & metabolic disorders
|October 30, 2024
PubMed
概括

益生菌 (PRL) 是一种关键激素,参与生殖和行为. 最近的研究揭示了它在偏头痛,新陈代谢,免疫和癌症中的多样性作用,提供了新的生理和病理生理学的见解.

关键词:
16kDa的前乳腺素是什么哺乳期 哺乳期 是一个下垂体 - - 下垂体孕产腺素是什么? 孕产腺素是什么?益生菌受体的受体是什么?信号传输 信号传输瓦索伊希比因 (Vasoinhibin) 是一种药物.

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科学领域:

  • 内分泌学 在内分泌学.
  • 分子生物学分子生物学
  • 生殖生物学 生殖生物学

背景情况:

  • 益生素 (PRL) 是一种具有多种功能的垂体激素.
  • PRL信号主要通过其受体 (PRLR) 涉及JAK2/Stat5通路.
  • 一种较短的形式,16kDa PRL ( Vasohinhibin),已经不完全理解信号传递.

研究的目的:

  • 审查益生素 (PRL) 的结构和信号.
  • 讨论PRL在生殖和行为中的正规作用.
  • 探索各种疾病中新兴的PRL功能.

主要方法:

  • 文献综述侧重于PRL结构,信号和功能.
  • 关于PRL信号的动物模型和人类遗传研究的分析.
  • 综合最近关于PRL参与非生殖过程的研究.

主要成果:

  • PRL对于生殖功能和母亲的行为至关重要.
  • PRL信号影响偏头痛,新陈代谢平衡和免疫反应.
  • 有证据表明,PRL与癌症的发展和进展有关.

结论:

  • 在繁殖之外,PRL表现出多方面的作用,影响了许多生理过程.
  • 了解PRL信号通路对于阐明其复杂功能至关重要.
  • 对PRL的进一步研究为各种疾病提供了潜在的治疗点.