基于多糖,结合物和mRNA的疫苗在患有尼瑟顿综合征的患者中具有免疫性
Anouk E M Nouwen1, Luca M Zaeck2, Renske Schappin1
1Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Journal of clinical immunology
|October 30, 2024
概括
尼瑟顿综合征 (NS) 患者对疫苗的免疫反应各异,大多数人对结合疫苗的反应正常,但对多糖疫苗的反应有所减少. 总的来说,免疫反应与健康个体相似,表明没有显著的B细胞或T细胞免疫缺陷.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 皮肤病学 皮肤病学
背景情况:
- 尼瑟顿综合征 (NS) 是一种罕见的遗传性皮肤疾病.
- 由于免疫失调,NS被归类为免疫的先天性错误 (IEI).
- 以前的研究没有发现B细胞和/或T细胞免疫缺陷的证据,但没有评估疫苗接种反应.
研究的目的:
- 评估成年NS患者对三个疫苗平台的免疫反应.
- 进一步调查NS中临床相关的B细胞和/或T细胞免疫缺陷的存在.
- 评估尼瑟顿综合征患者的疫苗疗效.
主要方法:
- 八名成年NS患者的横截面研究.
- 对多糖体 (PPV23) 和结合体 (ActHiB) 疫苗的评估免疫反应.
- 测量了mRNA COVID-19增强疫苗接种后的SARS-CoV-2特异性抗体和T细胞反应.
主要成果:
- 没有患者患有可归因于B细胞或T细胞免疫缺陷的感染.
- 7/7患者对ActHiB的正常免疫反应;对PPV23的多种反应 (1/7不存在,2/7减弱,4/7正常).
- 与对照组相比较的SARS-CoV-2抗体和CD4+T细胞反应;在4/6个NS患者中降低了CD8+T细胞反应.
结论:
- 在NS患者中,可以检测到疫苗诱导的免疫反应,跨越多糖,合和mRNA平台.
- 观察到疫苗反应的频谱,与健康的对照人群重叠.
- 这些发现表明,NS患者通常保持了足够的免疫反应接种疫苗.
更多相关视频
08:10Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
Published on: November 28, 2018
8.5K
00:10Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
Published on: August 21, 2019
7.5K
相关概念视频
Conjugated Proteins
18.2K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.2K
Antigens Involved in Adaptive Immunity
463
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
463
Vaccinations
44.1K
Overview
44.1K
