在各种癌症中Shugoshin 1表达:治疗的潜在目标
Indumathi Ankathatti Narayanaswamy1, Abhay Kumaraswamy Kattepur2, Kalyani Raju3
1Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research (Deemed to be University), Kolar, Karnataka, 563 103, India.
概括
舒戈辛1 (SGO1) 在许多癌症中高度表达,促进了扩散和转移. 用siRNA/shRNA准SGO1有效地减少了癌症的生长,并增加了对化疗的敏感性.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 舒戈辛1 (SGO1) 对于细胞分裂期间的中粒体保护和染色体分离至关重要.
- 改变SGO1表达与各种癌症和遗传疾病有关,表明其治疗潜力.
研究的目的:
- 在各种癌症模型中审查SGO1基因和蛋白质表达的文献.
- 评估在癌症治疗中使用siRNA/shRNA向SGO1的疗效.
主要方法:
- 在癌症细胞系,动物模型和患者组织中SGO1表达的文献综述.
- 使用小干扰RNA (siRNA) 和短毛RNA (shRNA) 对SGO1向的分析.
主要成果:
- 在多种癌症类型 (前列腺癌,癌,肺癌,乳腺癌等) 中观察到SGO1mRNA和蛋白质水平升高. ),与增加的扩散,入侵和转移有关.
- 在小鼠中SGO1淘汰/哈普洛因缺乏导致染色体不稳定性和瘤发生.
- 患者瘤中较高的SGO1表达与晚期,等级,大小和荷尔蒙状况相关,并与化学抵抗有关.
- 通过siRNA/shRNA击败SGO1,减少了癌细胞的增殖,诱导了细胞亡,并增加了对化疗剂的敏感性.
结论:
- 在各种癌症中,SGO1被显著上调,作为瘤进展的驱动因素.
- 用siRNA/shRNA向SGO1代表了一种有前途的治疗策略,可以抑制癌症生长,转移,并克服化学抵抗.
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