在Mycoplasma synoviae表面的延长因子G作为细胞粘附剂,通过结合维丁,促进对突膜细胞的粘附
1National Research Center of Veterinary Biologicals Engineering and Technology, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture and Rural Affairs, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou 225300, China; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; School of Life Sciences, Jiangsu University, Zhenjiang 212013, China; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
神经质突 (Mycoplasma synoviae) 使用延长因子G (EF-G) 结合突膜细胞,与维丁相互作用. 这种相互作用是细菌粘附和突炎的关键,为新疗法提供了点.
科学领域:
- 兽医微生物学 兽医微生物学
- 分子病原体的产生.
- 禽类的健康 禽类的健康
背景情况:
- 在全球范围内,Mycoplasma synoviae感染在家禽行业造成了重大经济损失.
- 背后的精确分子机制 M. synoviae 结膜体的殖民化和随后的结膜炎仍然在很大程度上是未知的.
研究的目的:
- 为了识别M. synoviae的膜蛋白,它们参与与突膜细胞 (SSCs) 的结合.
- 阐明已识别的蛋白质在粘附过程和M. synoviae诱导的突炎中的作用.
主要方法:
- 德西奥比奥丁拉下测试与液体染色学-并联质谱相结合,以选M. synoviae膜蛋白.
- 殖民地涂抹,双光,间接免疫光,以及ELISA用于蛋白质定位和结合试验.
- 共同免疫沉,GST拉下,细菌双杂交和siRNA干扰,用于相互作用和粘附研究.
主要成果:
- 延长因子G (EF-G) 被确定为一种位于表面的M. synoviae蛋白质和一种新型细胞粘合物.
- EF-G直接与SSC上的细胞表面受体维门结合.
- 无论是EF-G还是维门丁都显著促进了M. synoviae对SSC的粘附,这对炎至关重要.
结论:
- EF-G作为一种新型细胞粘合素,在SSC上与维丁结合,以促进M. synoviae的粘附.
- 这种EF-G-vimentin相互作用是M. synoviae殖民和突炎的关键因素.
- 这些发现为控制家禽中M. synoviae感染提供了潜在的治疗点.
相关概念视频
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cytoskeletal Accessory Proteins
Adherens Junctions
Adherens Junctions are Dynamic
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Intracellular Signaling Affects Focal Adhesions
Some...
Fimbriae, Pili, and Axial Filaments


