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Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

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波斯人群中的多发性硬化症相关性脑膜炎,一个多中心研究.

Pasha Anvari¹, Sahba Fekri², Alireza Hedayatfar³

¹Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Multiple sclerosis and related disorders

|October 30, 2024

概括

此摘要是机器生成的。

波斯人的多发性硬化症相关性脑膜炎 (MSU) 通常呈现为女性的慢性双边中间脑膜炎,有时模仿不分化的中间脑膜炎. 早期神经影像建议在高MS患病率地区对疑似病例进行早期神经影像.

关键词:

脱化斑块相关的紫外线炎颗粒状的角质沉物沉.多发性硬化症相关的脑膜炎神经成像是一种神经成像.视网膜血管炎视网膜血管炎没有区分的中间性脑膜炎.

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科学领域:

眼科医生眼科眼科
神经学神经学
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
尿道炎,眼睛血管层的炎症,可能与MS有关.
了解MS相关性脑膜炎 (MSU) 的特征对于及时诊断和管理至关重要.

研究的目的:

在波斯人群中描述多发性硬化症相关的脑膜炎 (MSU).
确定MSU的流行病学,临床和视觉结果模式.

主要方法:

追溯的,非随机的,多中心研究.
对92名MSU患者的流行病学数据,眼睛和神经学发现,血管学特征和视觉结果的分析.
对光素血管学 (FA) 发现和视力损伤的原因的审查.

主要成果:

MSU主要影响女性 (84.8%),平均年龄为35.9岁,经常呈现为双边中间性脑膜炎 (84.8%),慢性粒状 (81.9%).
在48.8%的病例中 (中位数为7年前),MS诊断之前有膜炎,在52.2%的病例中 (中位数为2年后) 随之而来.
周围视网膜周围血管泄漏 (81.4%) 和光盘高光 (74.4%) 是常见的FA发现;白内障 (52.7%) 和囊性黄斑胀 (31.5%) 是视力受损的主要原因.

结论:

MSU通常表现为慢性,双边,粒状中间性脑膜炎,特别是在女性中,并且可以呈现为孤立的前面脑膜炎或视网膜血管炎.
从临床角度来看,MSU可能类似于不分化的中间性脑膜炎,这凸显了在特有地区需要神经成像的需要.
扩展神经影像治疗慢性粒状卵膜炎的指示,特别是视网膜血管炎,建议在MS患病率高的地区使用.