射频电磁场对哺乳动物细胞的基因毒性在体外:一个系统的审查与叙事合成
Stefania Romeo1, Anna Sannino1, Maria Rosaria Scarfì1
1Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124, Napoli, Italy.
Environment international
|October 30, 2024
概括
这次系统性审查发现,证据表明射频电磁场 (RF-EMF) 在哺乳动物细胞中引起基因毒性作用的信心较低. 大多数研究没有显示出显著的基因毒性影响,这表明RF-EMF在体外并没有增加这些效应.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 人们越来越担心无线技术发出的射频电磁场 (RF-EMF) 对健康的潜在风险.
- 国际癌症研究机构在2011年将RF-EMF归类为可能致癌的物质,但证据很弱.
- 缺乏最新的RF-EMF基因毒性系统审查,特别是机理学研究.
研究的目的:
- 系统地审查在体外实验模型中RF-EMF诱导的基因毒性影响的科学文献.
- 评估RF-EMF在哺乳动物细胞培养物中诱导的基因毒性作用的信心和证据水平.
主要方法:
- 按照NTP-OHAT指南进行的系统文献审查,适用于体外研究.
- 搜索数据库 (NCBI PubMed,科学网,EMF门户) 截至 2022 年 12 月 31 日.
- 证据的叙述综合,按终点和暴露参数表格化数据;符合PRISMA 2020标准.
主要成果:
- 在7750个独一无二的记录中,包括了159篇包含1111个实验的文章.
- 80%的实验没有显示出RF-EMF暴露的统计学上显著的基因毒性影响.
- 大多数报告积极影响的研究质量中等至低,存在重大偏差问题.
结论:
- 这是使用透明方法和偏差评估在哺乳动物细胞培养物中RF-EMF基因毒性的第一个系统性审查.
- 对RF-EMF诱导基因毒性影响的证据的总体信心是"低".
- 适度的证据表明,射频电磁场暴露不会增加体外基因毒性作用,特别是不可逆转的终点.
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