调节的蛋白质分解诱导了生物分子凝聚物的异常阶段过渡到聚合物:护航群的保护作用

Janine Kamps1, Patricia Yuste-Checa2, Fatemeh Mamashli1

  • 1Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University, Bochum, Germany.

PubMed
概括

只有在液-液相分离 (LLPS) 后,蛋白蛋白 (PrP) 的蛋白酶裂变才会诱导有毒聚合物. 集群蛋白阻止这种聚合和子的传播,作为一种保护因素.

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