遗传证据将视网醇与出生体重联系起来:一项两样本的门德尔随机化研究
Fangxiang Mu1, Kexin Wang1, Lu Jiang1
1Department of Reproductive Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China.
Reproductive toxicology (Elmsford, N.Y.)
|October 30, 2024
概括
这项研究发现了视网醇和出生体重之间的因果关系,这表明怀孕期间足够的维生素A水平可以预防低出生体重. 其他抗氧化维生素对妊娠结果没有显著影响.
科学领域:
- 营养流行病学 营养流行病学
- 孕产妇和儿童的健康
- 遗传流行病学遗传流行病学
背景情况:
- 饮食中的抗氧化维生素对孕产妇和胎儿的健康至关重要.
- 以前的观察性研究表明,维生素和怀孕结果之间存在联系,但因果证据有限.
- 门德尔随机化 (MR) 提供了一种强大的方法,可以使用遗传变异推断因果关系.
研究的目的:
- 研究饮食中抗氧化维生素 (视网醇,维生素C,胡卜素,维生素E) 对妊娠关键结果的潜在因果影响.
- 特别是检查与流产,早产和出生体重的关联.
- 为产前维生素补充提供基于证据的建议.
主要方法:
- 采用孟德尔的随机化 (MR) 分析,使用单核酸多态 (SNP) 作为仪器变量.
- 利用了针对怀孕结果的大规模全基因组关联研究 (GWAS) 的总结统计数据.
- 应用反变量加权 (IVW) 方法与灵敏度分析 (MR-RAPS,最大概率),以确保结果的稳定性.
主要成果:
- 确定了视网醇对出生体重的显著因果作用 (β=0.091,P=0.028),得到了灵敏度分析的支持.
- 在视网醇和流产或早产之间没有发现统计学上显著的因果关系.
- 胡卜素,维生素E和维生素C与流产,早产或出生体重没有显著的因果关系.
结论:
- 雷丁醇的摄入对出生体重有因果影响,这凸显了怀孕期间维生素A水平充足的重要性.
- 维持正常的视网醇水平可能是防止低出生体重的可行策略.
- 在缺乏维生素A的孕妇中,监测和补充维生素A可以改善整体妊娠结果.
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