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用剂量密集的新辅助化疗治疗的乳腺癌患者免疫活动变化的预测值:一项回顾性研究
Wataru Goto1, Saeko Henmi1, Hanae Matsuda1
1Department of Breast Surgical Oncology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Anticancer research
|October 30, 2024
概括
剂量密集的新辅助化疗 (ddNAC) 并没有显著改善乳腺癌患者的病理完整反应率. 在ddNAC期间观察到免疫标记物变化,但无法预测治疗反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 建议给高风险乳腺癌患者进行剂量密集化疗.
- 与标准疗法相比,剂量密集的新辅助化疗 (ddNAC) 的疗效仍在争论中.
- 对ddNAC反应的预测标记需要进一步调查.
研究的目的:
- 评估免疫活动对接受ddNAC的乳腺癌患者短期结果的预测价值.
- 为了比较正常剂量和ddNAC疗法之间的病理完整响应 (pCR) 率.
主要方法:
- 对82名接受新辅助化疗 (NAC) 治疗的HER2-阴性乳腺癌患者的回顾性分析.
- 患者被分为正常剂量 (n=62) 和ddNAC (n=20) 组.
- 免疫标记物 (淋巴细胞计数,中性粒细胞与淋巴细胞的比率) 和瘤透淋巴细胞在pCR的关系下进行了评估.
主要成果:
- 两组之间临床病理特征没有显著差异.
- 在ddNAC组 (35.0%) 和正常剂量组 (25.8%) 中,pCR率在数值上更高,但在统计学上并不显著 (p=0.264).
- ddNAC治疗导致绝对淋巴细胞数量减少和中性粒细胞与淋巴细胞的比率增加,与pCR没有显著的相关性.
结论:
- ddNAC会影响系统外周免疫标记物.
- 目前的免疫标记物,包括外围标记物和瘤透性淋巴细胞,不是对ddNAC的反应的可靠预测剂.
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