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Updated: Jun 9, 2025

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化合物#41通过抑制Wnt/β-catenin信号通路来向急性髓性白血病

Yuki Hadate1, Yasunao Hattori2, Yuki Toda1

  • 1Laboratory of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan.

Anticancer research
|October 30, 2024
PubMed
概括

一种新型化合物,#41,在急性髓性白血病 (AML) 细胞中有效抑制了Wnt/β-catenin通路. 这种化合物抑制了瘤生长,诱导了亡,并在临床前模型中改善了生存率,提供了一个有前途的AML治疗策略.

关键词:
患有急性骨髓性白血病的人群.在 CTNNB1 找在Wnt/β-catenin信号通路中.灭症 (apoptosis) 是一种死亡的过程.

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