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氧化对SLE患者怀孕结果的影响:系统性审查和元分析

Qingmiao Zhu¹, Jiayu Wang², Qice Sun³

¹School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Lupus science & medicine

|October 30, 2024

概括

在患有全身性红斑狼 (SLE) 的孕妇中使用基 (HCQ) 与疾病活动和不良妊娠结果的风险降低有关. 这一发现支持HCQQ.

科学领域:

风湿病学和免疫学
孕产妇和胎儿医学孕产妇和胎儿医学
药理学药理学是指药理学的学科.

背景情况:

系统性红斑狼 (SLE) 在怀孕期间存在风险.
基氨酸 (HCQ) 是一种常见的SLE治疗方法.
关于孕妇SLE患者使用HCQ的先前研究产生了不一致的结果.

研究的目的:

评估氧化 (HCQ) 对SLE妇女怀孕相关结果的影响.
综合现有关于HCQ在怀孕期间SLE管理中的作用的证据.

主要方法:

在多个数据库 (PubMed,EMBASE,Cochrane图书馆,科学网,CNKI,万芳,VIP) 进行系统的文献搜索.
包括21项研究,包括929名HCQ使用者和1031名非使用者.
使用随机或固定的效果模型来评估聚合效应和异质性的元分析.

主要成果:

在第二和第三个季度,HCQ使用显著降低了SLEDAI得分.
高血压与较低的疾病爆发风险,早产,子宫内生长迟缓 (IUGR),妊娠高血压和子宫前有关.
HCQ的使用与预产期出生的可能性增加相关.
发现疾病爆发的高度异质性;检测到的出版偏差是为满期分娩.

结论:

这一元分析支持HCQ在患有SLE的孕妇的治疗疗效.
使用HCQ与更好的疾病控制和改善妊娠结果有关.
证据支持SLE患者在整个怀孕期间继续接受HCQ治疗.

关键词:

抗风湿剂抗风湿剂抗风湿剂自免疫性疾病自免疫性疾病红斑狼,全身性红斑狼

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