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高内皮静脉新生与肺腺癌中瘤微环境之间的组织病理相关性

Ato Sugiyama¹, Tai Hato², Hiroaki Kashimada¹

¹Department of General Thoracic Surgery, Saitama Medical Centre, Saitama Medical University, Saitama, Japan.

In vivo (Athens, Greece)

|October 30, 2024

概括

肺腺癌中的高内皮静脉 (HEV) 与免疫细胞积累有关,而不是整体血管结构. 免疫细胞群促进HEV成熟,这表明瘤进展中存在明显的血管新生机制.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
血管生物学血管生物学

背景情况:

瘤微环境的动态在癌症进展过程中演变.
高内皮静脉 (HEV),类似于淋巴结中的高内皮静脉,在瘤中越来越多地被识别出来.
以前的研究表明,抗血管生成疗法可以促进HEV的形成,但它们与瘤血管系统的关系尚不清楚.

研究的目的:

调查瘤血管结构与肺腺癌中高内皮静脉 (HEV) 新生之间的组织学相关性.
探索瘤微环境中的HEVs,先前存在的血管和间歇性纤维之间的关系.

主要方法:

对109名患有病态I期肺腺癌的患者的分析.
使用反外围节点地址因 (PNAd) 染色来识别HEV.
在瘤部分的免疫染色和Elastica-Masson-Goldner染色的量化.

主要成果:

在93.6%的患者中发现了外周节点地址因 (PNAd) 阳性细胞 (HEV),主要是在免疫细胞集群附近.
在HEV存在/密度和一般的微血管结构或间歇性纤维之间没有观察到显著的相关性.
具有丰富的HEV的免疫细胞聚合物显示出微血管密度增加,原蛋白的生产,以及更成熟的HEV形态.

结论:

瘤中的HEV生成遵循与更广泛的瘤微环境分开的血管生成机制.
免疫细胞的积累与肺腺癌中HEVs的增强成熟有关.

关键词:

高的内皮静脉静脉 (High endothelial venules) 是一个内皮静脉.原蛋白纤维是一种纤维.肺部腺癌的癌症.微型血管密度的密度周边淋巴结的周边淋巴结.

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